Tumorigenic Effect of Some Commonly Used Moisturizing Creams – Journal of Investigative Dermatology
Categories: Blog
Irradiation of SKH-1 mice with UVB (30 mJ cm−2) twice a week for 20 weeks resulted in mice with a high risk of developing skin tumors over the next several months in the absence of further irradiation with UVB (high-risk mice). Topical applications of 100 mg of Dermabase, Dermovan, Eucerin Original Moisturizing Cream (Eucerin), or Vanicream once a day, 5 days a week for 17 weeks to these high-risk mice increased significantly the rate of formation of tumors and the rate of increase in tumor size per mouse. Additional studies indicated that treatment of high-risk mice with Dermabase, Dermovan, Eucerin, or Vanicream for 17 weeks increased the total number of histologically characterized tumors by 69% (average of two experiments; P<0.0001 in each experiment), 95% (P<0.0001), 24% (P<0.01), and 58% (P<0.0001), respectively. Topical applications of a specially designed Custom Blend cream to high-risk mice was not tumorigenic. The results indicate that several commercially available moisturizing creams increase the rate of formation and number of tumors when applied topically to UVB-pretreated high-risk mice.
Four Cow Farm was started by a Midwife, Mum & Grandmother who wanted to make the best possible skincare products for her two little grandchildren (one of whom has eczema). Nanna's labour of love began as a gift to her two little ones. Today, the whole family is committed to providing 'nothing but the best' natural skincare products from our farm in the Blackall Mountain Range of South East Queensland (which runs on 100% green energy!)
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